NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are 3 plus-money bets to consider.
Introduction to Week 6 Picks
By Spenser Davis, published on Oct 12, 2025. This article contains references to products from advertisers or partners, and compensation may be received for clicking on links.
Past Performance
Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since Week 3, picks in this story have gained 2.16 units.
This Week's Predictions
Here are 3 bold predictions for Week 6:
- Fading the Colts offense may not be the wisest choice, but there's a case for doing so.
Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if maintained all season.
Author's summary: NFL Week 6 plus-money bets and predictions.