A global review highlights embryo metabolomics in spent culture media as a promising non-invasive method for embryo selection, paving the way for AI-integrated IVF tools.
NEW research has spotlighted embryo metabolism analysis as a potential next-generation method for non-invasive embryo selection in IVF. By studying the nutrients consumed and released by embryos in their spent embryo culture media (SECM), researchers propose that metabolic profiling could complement existing tools such as morphology and genetics to improve implantation and pregnancy outcomes.
The review, led by AliReza Alizadeh Moghadam Masouleh and colleagues, analysed 49 studies conducted between 1989 and 2024 across 20 countries, evaluating how metabolic by-products in SECM correlate with embryo viability.
Author's summary: Metabolism analysis may improve IVF success.