Oncolytics Biotech Inc. announced updated results from the GOBLET study, showing that pelareorep plus atezolizumab achieves a 30% objective response rate (ORR) in second-line or later squamous cell anal carcinoma (SCAC) patients.
This compares to a 13.8% ORR for the current FDA-approved second-line treatment. The median duration of response was 15.5 months, compared to 9.5 months for the standard of care.
Pelareorep plus atezolizumab achieves 30% ORR in second-line or later (≥2L) squamous cell anal carcinoma (SCAC) relative to 13.8% for the FDA-approved 2L treatment
The company expects to discuss a single-arm accelerated approval study with the FDA in Q1 2026.
Author's summary: Oncolytics Biotech reports promising anal cancer data.